Journal Club : Dobutamine-Noradrenaline vrs Adrenaline in cardiogenic shock

Neil Orford on 27-03-2011

Researchers have just released findings of a prospective randomised trial comparing adrenaline with dobutamine and noradrenaline for the treatment of "dopamine resistant" cardiogenic shock. The paper found that there was no difference in attainment of haemodynamic endpoints, but there was an increase in the likelihood of arrhythmias, transient lactic acidosis and splanchnic perfusion as measured by gastric tonometry. This is a small study with surrogate endpoints, but hints again that there are limited differences between the available inotropic agents.

1 Comments

Got something to say?

Log in to your account

Forgotten your password?

Todd Fraser wrote 10-07-2012 10:48:52 am
You know, I don't know a whole lot about inotropes, not like John Myburgh does. So I asked him. Check out his podcast interview here - http://crit-iq.com/index.php/podcast