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The PROTECT trial published in NEJM
Neil Orford on 2011-03-23 12:25:00
The PROTECT trial is another incredible ANZICS CTG effort, in conjunction with the Canadian CTG. This 3764 participant, db, mulitcentre, international, RCT, compared dalteparin to ...
Journal Club : After hours and weekend admission to ICU increases mortality
Neil Orford on 2011-03-27 13:12:00
This retrospective cohort study of all admissions to adult ICU's in Australia from 1st Jan 2000-31Dec 2008 examined the relationship between time of admission to ICU and mortality....
Journal Club : Dobutamine-Noradrenaline vrs Adrenaline in cardiogenic shock
Neil Orford on 2011-03-27 13:22:00
Researchers have just released findings of a prospective randomised trial comparing adrenaline with dobutamine and noradrenaline for the treatment of "dopamine resistant" cardiogen...
Journal Club : DECRA - decompressive craneictomy for refractory intracranial hypertension in TBI
Neil Orford on 2011-03-27 13:09:00
For several years now, neurosurgeons and intensivists have speculated that decrompression of the cranial vault in patients with severe refractory intracranial hypertension may impr...
Journal Club : HYPOLYTE - do steroids reduce hospital acquired pneumonia in multitrauma patients
Todd Fraser on 2011-03-29 09:59:00
The HYPOLYTE trial, released in JAMA in March, raises more questions than it answers.
The trial, conducted in 7 ICUs over 3 years, randomised 150 patients to "stress dose" stero...
Journal Club : The PROTECT study
Neil Orford on 2011-03-27 13:13:00
The PROTECT trial is another incredible ANZICS CTG effort, in conjunction with the Canadian CTG. This 3764 participant, double blinded, multicentre, international, randomised contr...
Reducing the burden of nosocomial organisms in ICU
Neil Orford on 2011-04-19 07:33:00
With 3 prospective trials, a retrospective trial, and an editorial focusing on measures to reduce nosocomial colonisations and infections in the ICU, it appears this burdensome se...
Journal Club : Permissive hypotension in trauma - does the evidence support the hype?
Todd Fraser on 2011-05-08 13:09:00
Did I just give away my position on this arguement?
This month we see the release of an interim analysis by a group from Texas, USA, led by the indefatiguable Ken Mattox. In th...
Journal Club : FEAST - a stunning new work in fluid resuscitation
Todd Fraser on 2011-06-02 08:45:00
This is a landmark paper in medicine, and is a remarkable achievement both in its scale and its contribution to medical knowledge.
It is a pragmatic, randomised, controlled tr...
Journal Club : Early versus late initiation of TPN in critically ill patients
Todd Fraser on 2011-07-01 16:52:00
The place of TPN is now reasonably well established in ICU patients - there is little evidence that it can be endorsed when there is a working alimentary tract. However, the timin...
Journal Club : NIV to liberate patients chronic respiratory failure from ventilators
Todd Fraser on 2011-07-05 11:13:00
Rationale: The interest of non-invasive ventilation (NIV) as an early weaning/extubation technique from mechanical ventilation remains controversial.
Objectives: To investigate...
Journal Club : Do we need to do more for the critically ill in regional areas?
Rajesh Krishnan on 2011-07-06 16:21:00
Critical access hospitals (CAH), a US initiative, are defined as no more than 25 acute care beds and more than 35 miles from the nearest hospital. The advantage of being designa...
Journal Club : DVT prophylaxis in patients with brain injury
Todd Fraser on 2011-08-31 09:03:00
September Journal Club begins with a pair of articles published this year on the controversial topic of brain injury and thromboprophylaxis.
Clearly, these patients are at heigh...
Why positive trials aren’t really positive, and negative ones may not be negative
Chris Poynter on 2014-02-18 19:43:55
Recently, I was pleasantly surprised with a discussion about statistics during one of our journal clubs. I know, I know, sounds crazy, but bear with ...
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