Journal Club - Recent Additions

April - 2020

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Compassionate Use of Remdesivir for Patients with Severe Covid-19

Jonathan Grein, Norio Ohmagari, Daniel Shin et al, NEJM, 2020, Online first

Comment

Remdesivir is a prodrug of a nucleotide analogue that is intracellularly metabolized to an analogue of ATP that inhibits viral RNA polymerases. It has broad-spectrum antiviral activity including filoviruses (e.g., Ebola) and coronaviruses (e.g., SARS-CoV and MERS-CoV), with some...


April



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