Journal Club - Recent Additions

February - 2020

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Effect of Vancomycin or Daptomycin With vs Without an Antistaphylococcal ?-Lactam on Mortality, Bacteremia, Relapse, or Treatment Failure in Patients With MRSA Bacteremia - The CAMERA2 Trial

S Tong, D Lye, D Yahav, et al for the Australasian Society for Infectious Diseases Clinical Research Network JAMA, 2020, 323(6):527-537

Comment

The mortality for S aureus bacteraemia is high, 20-25%. It is higher for MRSA than MSSA. Standard therapy for MRSA is vancomycin or da-tony in, and they have shortcomings, ie poor tissue penetration and slow killing time. There is in-vivo and in-vitro evidence that adding a...


February



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