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July - 2016

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Inflammation and Organ Failure Severely Affect Midazolam Clearance in Critically Ill Children

N Vet, J Brussee, M de Hoog, et al for the SKIC (Dutch collaborative PICU research network) Am J Resp Crit Care Med, 2016, 194(1);58-66

Comment

This prospective observational study, conducted within a multicenter RCT of daily sedation interruption in  critically ill children, examined the relationship between organ failure, inflammation, and midazolam clearance and metabolism. The cytochrome P-450...


July



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