July - 2016
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Inflammation and Organ Failure Severely Affect Midazolam Clearance in Critically Ill ChildrenN Vet, J Brussee, M de Hoog, et al for the SKIC (Dutch collaborative PICU research network) Am J Resp Crit Care Med, 2016, 194(1);58-66 This page is only available to Crit-IQ subscribers. To view the rest of this review and gain access to our vast array of critical care teaching tools including podcasts, vodcasts, modules, exam preparation tools, teaching aids and much more, login here, or Become a Member to register |
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This prospective observational study, conducted within a multicenter RCT of daily sedation interruption in critically ill children, examined the relationship between organ failure, inflammation, and midazolam clearance and metabolism. The cytochrome P-450...