October - 2014
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Simvastatin in the Acute Respiratory Distress SyndromeDaniel F. McAuley, John G. Laffey, Cecilia M. O’Kane, et al for the Irish Critical Care Trials Group NEJM, 2014, Online 1st 30th Sept This page is only available to Crit-IQ subscribers. To view the rest of this review and gain access to our vast array of critical care teaching tools including podcasts, vodcasts, modules, exam preparation tools, teaching aids and much more, login here, or Become a Member to register |
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The hypothesis that statins could modify the inflammatory process in ARDS and improve outcomes is biologically plausible. This prospective RCT randomised 540 patients with ARDS for less than 48 hours to simvastatin (enteral 80mg daily for 28-days) or placebo in 40 ICUs in the UK...