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July - 2014

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Showing Journal 9 of 12

Oxygenation Response to Positive End-Expiratory Pressure Predicts Mortality in Acute Respiratory Distress Syndrome - A Secondary Analysis of the LOVS and ExPress Trials

Edwan C Goligher, Brian P Kavanagh, Gordon Rubenfeld, et al Am J Resp Crit Care Med, 2014, 190(1);70-76

Comment

Best PEEP in ARDS remains an elusive goal, with varying outcomes from ARDS trials. This secondary analysis of the LOVS and ExPress trials (negative studies of high vs lower PEEP in ARDS), explores the possibly that the oxygenation response to PEEP may predict outcome, i.e....

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July

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Readers Comments - 1

Previous Comments

Can I clarify what people would classify as high and low PEEP? the groups used in LOVS and ExPress were 10vs 15cmH2O and 7vs13 cmH2O respectively. Whereas the ARDSnet ventilator protocol goes up to 24cmH20 - where is the evidence for the very high PEEP coming from?
c-12 Jul, 2014 03:40:24 PM