July - 2013
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An Adaptive, Phase II, Dose-Finding Clinical Trial Design to Evaluate L-Carnitine in the Treatment of Septic Shock Based on Efficacy and Predictive Probability of Subsequent Phase III SuccessRoger J. Lewis, Kert Viele, Kristine Broglio, Scott M. Berry, Alan E. Jones Crit Care Med, 2013, 41:1674-1678 This page is only available to Crit-IQ subscribers. To view the rest of this review and gain access to our vast array of critical care teaching tools including podcasts, vodcasts, modules, exam preparation tools, teaching aids and much more, login here, or Become a Member to register |
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This paper is interesting as it describes a proposal to use an adaptive design to identify the dose of L-carnitine that provides the greatest improvement in SOFA score in septic shock. As such it is a good educational resource if you are interested in trying to understand adapative design...