September - 2012
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Corticosteroid resistance in sepsis is influenced by microRNA-124–induced downregulation of glucocorticoid receptor-alphaLedderose, Carola; Möhnle, Patrick; Limbeck, Elisabeth; Schütz, Stefanie; Weis, Florian; Rink, Jessica; Briegel, Josef; Kreth, Simone Crit Care Med, 2012, 40:2745–2753 This page is only available to Crit-IQ subscribers. To view the rest of this review and gain access to our vast array of critical care teaching tools including podcasts, vodcasts, modules, exam preparation tools, teaching aids and much more, login here, or Become a Member to register |
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The role of physiological dose corticosteroid replacement in septic shock continues to perplex us.
Relative adrenal insufficiency and steroid resistance in tissue cells. The immunomodulatory effects of glucocorticoids (GCs) are mediated by the GC receptor alpha (GR A), although...