June - 2012
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Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysisKatharine Ker, Phil Edwards, Pablo Perel, et al. BMJ, 2012, 344:e3054 This page is only available to Crit-IQ subscribers. To view the rest of this review and gain access to our vast array of critical care teaching tools including podcasts, vodcasts, modules, exam preparation tools, teaching aids and much more, login here, or Become a Member to register |
June |
Previous Comments
| You should also read the editorial associated with this, which basically says "the evidence is there so stop doing all these little trials on every different operation". TXA is dirt cheap (less than $100 per patient treatment) and appears safe based on the CRASH2 data [disclaimer - I was a CRASH2 investigator and may have a biased interpretation!]. I believe on current evidence TXA to be indicated in any elective surgery with a predicted need for blood transfusion, as well as any major trauma with significant blood loss. Certainly in my anaesthetic practise I am now using TXA routinely in my multilevel lumbar spine fixations, and frequently get by with just CellSaver and TXA, postop iron and no homologous transfusion at all. As noted the results of ATACAS will be interesting. | |
| Ian Seppelt-24 Jun, 2012 11:02:41 PM | |
Comment
The conclusion sums it up nicely, tranexamic acid reduces bleeding and blood transfusion, although the effect on thromboembolic events is not...