June - 2012
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An observational study fluid balance and patient outcomes in the randomized evaluation of normal vs. augmented level of replacement therapy trial*The Renal Replacement Therapy Study investigators Crit Care Med, 2012, 40:1753-1760 This page is only available to Crit-IQ subscribers. To view the rest of this review and gain access to our vast array of critical care teaching tools including podcasts, vodcasts, modules, exam preparation tools, teaching aids and much more, login here, or Become a Member to register |
June |
Previous Comments
| Not surprised with this emerging evidence that more fluids kill people and IVF should be considered as drug with known adverse effects which are emerging from these recent RCT's. Similar results were seen in the post hoc analysis of the FACTT study which showed a posi- tive fluid balance after AKI was associated with 60-day mortality in patients with ALI. In this study, the risk of death was approximately 1.6-fold higher per L/d of fluid accumulated. Though both these studies were post hoc analysis, there is sufficient enough hypothesis generating data that negative fluid balance is associated with improved outcome in AKI which needs to be addressed in a large RCT. | |
| Mahadev Patil-18 Jun, 2012 06:59:01 AM | |
Comment
This analysis of data from the RENAL trial challenges the notion that liberal fluid administration is beneficial, particularly for the kidney.
The authors compared the RENAL patients with a positive mean daily fluid balance to those with a negative mean daily fluid...