March - 2012
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Dexmedetomidine vs Midazolam or Propofol for Sedation During Prolonged Mechanical Ventilation: Two Randomized Controlled TrialsThe Dexmedetomidine for Long-Term Sedation Investigators JAMA, 2012, March 21, 2012 This page is only available to Crit-IQ subscribers. To view the rest of this review and gain access to our vast array of critical care teaching tools including podcasts, vodcasts, modules, exam preparation tools, teaching aids and much more, login here, or Become a Member to register |
March |
Previous Comments
| Importantly, note the time taken between ICU admission (with sedation) and recruitment into these trials. This is an important confounder which may dilute any possible benefit and is very relevant to the planned ANZ SPICE trial which will aim to recruit as soon as possible after ICU admission (and at most only 12 hours). This depends on ethical acceptance of delayed consent for these patients, and these two trials (MIDEX and PRODEC) will strengthen that ethical argument, at least in terms of safety. Ian Seppelt | |
| Ian Seppelt-26 Mar, 2012 01:53:20 AM | |
Comment
There has been a renewal of interest in dexmedetomidine for sedation, and prevention or treatment for agitated delirium in critically ill patients. This paper presents the results of 2 multi-center phase 3 trials in Europe, comparing dex to midazolam or propofol for sedation.
Dex was...