February - 2012
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Proton Pump Inhibitors vs. Histamine 2 Receptor Antagonists for Stress-Related Mucosal Bleeding Prophylaxis in Critically Ill Patients: A Meta-AnalysisAlan N Barkun, Marc Bardou, C Q D Pham and Myriam Martel American Journal of Gastrenterology, 2012, Published online ahead of print This page is only available to Crit-IQ subscribers. To view the rest of this review and gain access to our vast array of critical care teaching tools including podcasts, vodcasts, modules, exam preparation tools, teaching aids and much more, login here, or Become a Member to register |
February |
Previous Comments
That's a bit odd - given the increasing evidence that PPIs increase the rates of community acquired pneumonia and VAP, I would have expected this would have been higher. Could this be because VAP is also increased by H2 antagonists? | |
Jean Bridie-19 Feb, 2012 01:26:45 PM | |
I think it is because , Vap is multi factorial , not just due to colonisation of stomach with bacteria .interesting to know whether there is increase in stomach colonisation on ppi use than h2 receptor. | |
Critq iq-15 Apr, 2013 08:37:23 AM | |
Comment
There is a general consensus that proton pump inhibitors are the best agents in at-risk patients for preventing gastrointestinal haemorrhage in ICU. However, recent research has raised concerns that their widespread use may increase risk of nosocomial pneumonia.
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