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February - 2012

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Showing Journal 9 of 15


Proton Pump Inhibitors vs. Histamine 2 Receptor Antagonists for Stress-Related Mucosal Bleeding Prophylaxis in Critically Ill Patients: A Meta-Analysis

Alan N Barkun, Marc Bardou, C Q D Pham and Myriam Martel American Journal of Gastrenterology, 2012, Published online ahead of print

Comment

There is a general consensus that proton pump inhibitors are the best agents in at-risk patients for preventing gastrointestinal haemorrhage in ICU.  However, recent research has raised concerns that their widespread use may increase risk of nosocomial pneumonia. 

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February



Previous Comments

That's a bit odd - given the increasing evidence that PPIs increase the rates of community acquired pneumonia and VAP, I would have expected this would have been higher. Could this be because VAP is also increased by H2 antagonists?
Jean Bridie-19 Feb, 2012 01:26:45 PM

I think it is because , Vap is multi factorial , not just due to colonisation of stomach with bacteria .interesting to know whether there is increase in stomach colonisation on ppi use than h2 receptor.
Critq iq-15 Apr, 2013 08:37:23 AM