January - 2012
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Enteral Omega-3 Fatty Acid, ³-Linolenic Acid, and Antioxidant Supplementation in Acute Lung InjuryTodd W. Rice, MD, MSc; Arthur P. Wheeler, MD; B. Taylor Thompson, MD; Bennett P. deBoisblanc, MD; Jay Steingrub, MD; Peter Rock, MD, MBA for the NIH NHLBI Acute Respiratory Distress Syndrome Network of Investigators JAMA, 2011, 306(14):1574-1581. This page is only available to Crit-IQ subscribers. To view the rest of this review and gain access to our vast array of critical care teaching tools including podcasts, vodcasts, modules, exam preparation tools, teaching aids and much more, login here, or Become a Member to register |
January |
Previous Comments
| Bummer. Back to vitalised Big Macs and Thickshakes... | |
| James O'Connor-24 Jan, 2012 06:20:43 PM | |
| No kidding. It seems all these "magic bullet" trials seem to fall apart when subjected to a properly conducted randomised controlled trial. | |
| Darren Cable-29 Jan, 2012 04:25:47 PM | |
| A couple of points - did the trial prove the groups were separated with respect to the interventions? There was an increase in n-3 lipids but no decrease in n-6 lipids. There was ultimately no change in the measured inflammatory mediators including IL-6, IL-8 and various leukotrienes. So, either the theory is wrong (changing lipids doesn't change inflammatory mediator concentrations), something else prevents this from happening, or the dose wasn't high enough. Is there any way of telling which of these it is? | |
| Jean Bridie-21 Feb, 2012 02:23:23 PM | |
| There is no information in this paper about the feeding that both groups had in addition to the intervention. I presume that if this was standard feeds it contained n-6 lipids. Is it possible then that this prevented the "anti-inflammatory" lipids from expressing an effect? | |
| Jo Butler-21 Feb, 2012 03:03:47 PM | |
Comment
Multiple smaller trials have demonstrated the potential effect of anti-inflammatory lipids in enteral feeds for patients with acute lung injury. In an attempt to solidify the evidence base for this, the NIH ARDS-NET crew have released this randomised trial.
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